Promega Corporation

CYP450 Assay Systems

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The P450-Glo™ CYP450 Assays provide a homogeneous, luminescent method for measuring cytochrome P450 activity. The assays are designed to measure the activities of P450s from recombinant and native sources and for testing the effects of analytes such as drugs and new chemical entities on P450 activities. These luminescent assays exhibit exquisite sensitivity, low background signals and broad dynamic range.

P450-Glo™ Assays employ luminogenic P450 substrates that are derivatives of beetle luciferin, a substrate for luciferase enzymes. The derivatives are not substrates for luciferase but are converted by P450s to l...

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Product Size Conc. Catalog # *List Price Order QTY Add to Cart

P450-Glo™ CYP1A2 Induction/Inhibition Assay

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P450-Glo™ CYP1A2 Induction/Inhibition Assay

 Components

  • Luciferin-1A2

    V841A1 x 30μl
  • D-Cysteine, 500X

    V843A1 x 100μl
  • Luciferin Detection Reagent

    V859A1 x 1 each
  • Reconstitution Buffer

    V865A1 x 10ml
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  • This product can be added to a

  • Helix Freezer

This product is available through the Promega Helix onsite stocking program in a –20°C Helix Freezer. The program offers numerous convenient solutions to meet your lab's needs. Helix Freezers are available in two sizes: 5.7 cubic ft. or 9.7 cubic ft.


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10ml
- V8421 C$ 146.00 Add to cart

P450-Glo™ CYP1A2 Induction/Inhibition Assay

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P450-Glo™ CYP1A2 Induction/Inhibition Assay

 Components

  • Luciferin-1A2

    V841A2 x 30μl
  • D-Cysteine, 500X

    V843A1 x 100μl
  • Luciferin Detection Reagent

    V859B1 x 1 each
  • Reconstitution Buffer

    V865B1 x 50ml
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  • This product can be added to a

  • Helix Freezer

This product is available through the Promega Helix onsite stocking program in a –20°C Helix Freezer. The program offers numerous convenient solutions to meet your lab's needs. Helix Freezers are available in two sizes: 5.7 cubic ft. or 9.7 cubic ft.


Click here to learn more about the Helix Collection »


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50ml
- V8422 C$ 429.00 Add to cart

P450-Glo™ CYP3A4 Assay with Luciferin-IPA

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P450-Glo™ CYP3A4 Assay with Luciferin-IPA

 Components

  • Reconstitution Buffer with esterase

    V144A1 x 10ml
  • Luciferin-IPA

    V840A1 x 15μl
  • Luciferin Detection Reagent

    V859A1 x 1 each
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  • This product can be added to a

  • Helix Freezer

This product is available through the Promega Helix onsite stocking program in a –20°C Helix Freezer. The program offers numerous convenient solutions to meet your lab's needs. Helix Freezers are available in two sizes: 5.7 cubic ft. or 9.7 cubic ft.


Click here to learn more about the Helix Collection »


Already a Helix Customer?

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10ml
- V9001 C$ 146.00 Add to cart

P450-Glo™ CYP3A4 Assay with Luciferin-IPA

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P450-Glo™ CYP3A4 Assay with Luciferin-IPA

 Components

  • Reconstitution Buffer with esterase

    V144B1 x 50ml
  • Luciferin-IPA

    V840B1 x 60μl
  • Luciferin Detection Reagent

    V859B1 x 1 each
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  • This product can be added to a

  • Helix Freezer

This product is available through the Promega Helix onsite stocking program in a –20°C Helix Freezer. The program offers numerous convenient solutions to meet your lab's needs. Helix Freezers are available in two sizes: 5.7 cubic ft. or 9.7 cubic ft.


Click here to learn more about the Helix Collection »


Already a Helix Customer?

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50ml
- V9002 C$ 429.00 Add to cart

P450-Glo™ CYP3A4 Assay (Luciferin-PPXE)
DMSO-Tolerant Assay

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P450-Glo™ CYP3A4 Assay (Luciferin-PPXE)
DMSO-Tolerant Assay

 Components

  • Luciferin Detection Reagent

    V859A1 x 1 each
  • Reconstitution Buffer

    V865A1 x 10ml
  • Luciferin-PPXE

    V997A1 x 15μl
10ml
- V8911 C$ 146.00 Add to cart

P450-Glo™ CYP3A4 Assay (Luciferin-PPXE)
DMSO-Tolerant Assay

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P450-Glo™ CYP3A4 Assay (Luciferin-PPXE)
DMSO-Tolerant Assay

 Components

  • Luciferin Detection Reagent

    V859B1 x 1 each
  • Reconstitution Buffer

    V865B1 x 50ml
  • Luciferin-PPXE

    V997A2 x 15μl
50ml
- V8912 C$ 429.00 Add to cart

P450-Glo™ CYP3A4 Assay (Luciferin-PFBE)
Cell-Based/Biochemical Assay

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P450-Glo™ CYP3A4 Assay (Luciferin-PFBE)
Cell-Based/Biochemical Assay

 Components

  • Luciferin Detection Reagent

    V859A1 x 1 each
  • Reconstitution Buffer

    V865A1 x 10ml
  • Luciferin-PFBE

    V873A1 x 500μl
10ml
- V8901 C$ 146.00 Add to cart

P450-Glo™ CYP3A4 Assay (Luciferin-PFBE)
Cell-Based/Biochemical Assay

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P450-Glo™ CYP3A4 Assay (Luciferin-PFBE)
Cell-Based/Biochemical Assay

 Components

  • Luciferin Detection Reagent

    V859B1 x 1 each
  • Reconstitution Buffer

    V865B1 x 50ml
  • Luciferin-PFBE

    V873A3 x 500μl
Close Window
  • This product can be added to a

  • Helix Freezer

This product is available through the Promega Helix onsite stocking program in a –20°C Helix Freezer. The program offers numerous convenient solutions to meet your lab's needs. Helix Freezers are available in two sizes: 5.7 cubic ft. or 9.7 cubic ft.


Click here to learn more about the Helix Collection »


Already a Helix Customer?

Request to add this product to your Helix »


50ml
- V8902 C$ 429.00 Add to cart

P450-Glo™ CYP1A1 Assay

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P450-Glo™ CYP1A1 Assay

 Components

  • Luciferin Detection Reagent

    V859A1 x 1 each
  • Luciferin-CEE, 5mM

    V863A1 x 70μl
  • Reconstitution Buffer

    V865A1 x 10ml
Close Window
  • This product can be added to a

  • Helix Freezer

This product is available through the Promega Helix onsite stocking program in a –20°C Helix Freezer. The program offers numerous convenient solutions to meet your lab's needs. Helix Freezers are available in two sizes: 5.7 cubic ft. or 9.7 cubic ft.


Click here to learn more about the Helix Collection »


Already a Helix Customer?

Request to add this product to your Helix »


10ml
- V8751 C$ 146.00 Add to cart

P450-Glo™ CYP1A1 Assay

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P450-Glo™ CYP1A1 Assay

 Components

  • Luciferin Detection Reagent

    V859B1 x 1 each
  • Luciferin-CEE, 5mM

    V863B1 x 350μl
  • Reconstitution Buffer

    V865B1 x 50ml
Close Window
  • This product can be added to a

  • Helix Freezer

This product is available through the Promega Helix onsite stocking program in a –20°C Helix Freezer. The program offers numerous convenient solutions to meet your lab's needs. Helix Freezers are available in two sizes: 5.7 cubic ft. or 9.7 cubic ft.


Click here to learn more about the Helix Collection »


Already a Helix Customer?

Request to add this product to your Helix »


50ml
- V8752 C$ 429.00 Add to cart

P450-Glo™ CYP1B1 Assay

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P450-Glo™ CYP1B1 Assay

 Components

  • Luciferin Detection Reagent

    V859A1 x 1 each
  • Luciferin-CEE, 5mM

    V863A1 x 70μl
  • Reconstitution Buffer

    V865A1 x 10ml
10ml
- V8761 C$ 146.00 Add to cart

P450-Glo™ CYP1B1 Assay

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P450-Glo™ CYP1B1 Assay

 Components

  • Luciferin Detection Reagent

    V859B1 x 1 each
  • Luciferin-CEE, 5mM

    V863B1 x 350μl
  • Reconstitution Buffer

    V865B1 x 50ml
50ml
- V8762 C$ 429.00 Add to cart

P450-Glo™ CYP1A2 Assay

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P450-Glo™ CYP1A2 Assay

 Components

  • Luciferin Detection Reagent

    V859A1 x 1 each
  • Luciferin-ME, 5mM

    V862A1 x 200μl
  • Reconstitution Buffer

    V865A1 x 10ml
10ml
- V8771 C$ 146.00 Add to cart

P450-Glo™ CYP1A2 Assay

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P450-Glo™ CYP1A2 Assay

 Components

  • Luciferin Detection Reagent

    V859B1 x 1 each
  • Luciferin-ME, 5mM

    V862B1 x 1ml
  • Reconstitution Buffer

    V865B1 x 50ml
50ml
- V8772 C$ 429.00 Add to cart

P450-Glo™ CYP2C8 Assay

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P450-Glo™ CYP2C8 Assay

 Components

  • Luciferin Detection Reagent

    V859A1 x 1 each
  • Luciferin-ME, 5mM

    V862C1 x 300μl
  • Reconstitution Buffer

    V865A1 x 10ml
10ml
- V8781 C$ 146.00 Add to cart

P450-Glo™ CYP2C8 Assay

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P450-Glo™ CYP2C8 Assay

 Components

  • Luciferin Detection Reagent

    V859B1 x 1 each
  • Luciferin-ME, 5mM

    V862D2 x 750μl
  • Reconstitution Buffer

    V865B1 x 50ml
50ml
- V8782 C$ 429.00 Add to cart

P450-Glo™ CYP2C9 Assay

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P450-Glo™ CYP2C9 Assay

 Components

  • Luciferin Detection Reagent

    V859A1 x 1 each
  • Luciferin-H, 5mM

    V864A1 x 200μl
  • Reconstitution Buffer

    V865A1 x 10ml
Close Window
  • This product can be added to a

  • Helix Freezer

This product is available through the Promega Helix onsite stocking program in a –20°C Helix Freezer. The program offers numerous convenient solutions to meet your lab's needs. Helix Freezers are available in two sizes: 5.7 cubic ft. or 9.7 cubic ft.


Click here to learn more about the Helix Collection »


Already a Helix Customer?

Request to add this product to your Helix »


10ml
- V8791 C$ 146.00 Add to cart

P450-Glo™ CYP2C9 Assay

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P450-Glo™ CYP2C9 Assay

 Components

  • Luciferin Detection Reagent

    V859B1 x 1 each
  • Luciferin-H, 5mM

    V864B1 x 1ml
  • Reconstitution Buffer

    V865B1 x 50ml
Close Window
  • This product can be added to a

  • Helix Freezer

This product is available through the Promega Helix onsite stocking program in a –20°C Helix Freezer. The program offers numerous convenient solutions to meet your lab's needs. Helix Freezers are available in two sizes: 5.7 cubic ft. or 9.7 cubic ft.


Click here to learn more about the Helix Collection »


Already a Helix Customer?

Request to add this product to your Helix »


50ml
- V8792 C$ 429.00 Add to cart

P450-Glo™ CYP3A4 Assay

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P450-Glo™ CYP3A4 Assay

 Components

  • Luciferin Detection Reagent

    V859A1 x 1 each
  • Reconstitution Buffer

    V865A1 x 10ml
  • Luciferin-BE, 5mM

    V866A1 x 100μl
10ml
- V8801 C$ 146.00 Add to cart

P450-Glo™ CYP3A4 Assay

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P450-Glo™ CYP3A4 Assay

 Components

  • Luciferin Detection Reagent

    V859B1 x 1 each
  • Reconstitution Buffer

    V865B1 x 50ml
  • Luciferin-BE, 5mM

    V866B1 x 500μl
50ml
- V8802 C$ 429.00 Add to cart

P450-Glo™ CYP3A7 Assay

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P450-Glo™ CYP3A7 Assay

 Components

  • Luciferin Detection Reagent

    V859A1 x 1 each
  • Reconstitution Buffer

    V865A1 x 10ml
  • Luciferin-BE, 5mM

    V866C1 x 300μl
10ml
- V8811 C$ 146.00 Add to cart

P450-Glo™ CYP3A7 Assay

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P450-Glo™ CYP3A7 Assay

 Components

  • Luciferin Detection Reagent

    V859B1 x 1 each
  • Reconstitution Buffer

    V865B1 x 50ml
  • Luciferin-BE, 5mM

    V866D2 x 750μl
50ml
- V8812 C$ 429.00 Add to cart

P450-Glo™ CYP2C19 Assay

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P450-Glo™ CYP2C19 Assay

 Components

  • Reconstitution Buffer with esterase

    V144A1 x 10ml
  • Luciferin Detection Reagent

    V859A1 x 1 each
  • Luciferin-H EGE

    V867A1 x 123μg
Close Window
  • This product can be added to a

  • Helix Freezer

This product is available through the Promega Helix onsite stocking program in a –20°C Helix Freezer. The program offers numerous convenient solutions to meet your lab's needs. Helix Freezers are available in two sizes: 5.7 cubic ft. or 9.7 cubic ft.


Click here to learn more about the Helix Collection »


Already a Helix Customer?

Request to add this product to your Helix »


10ml
- V8881 C$ 146.00 Add to cart

P450-Glo™ CYP2C19 Assay

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P450-Glo™ CYP2C19 Assay

 Components

  • Reconstitution Buffer with esterase

    V144B1 x 50ml
  • Luciferin Detection Reagent

    V859B1 x 1 each
  • Luciferin-H EGE

    V867A2 x 123μg
50ml
- V8882 C$ 429.00 Add to cart

P450-Glo™ CYP2D6 Assay

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P450-Glo™ CYP2D6 Assay

 Components

  • Reconstitution Buffer with esterase

    V144A1 x 10ml
  • Luciferin Detection Reagent

    V859A1 x 1 each
  • Luciferin-ME EGE

    V869A1 x 240μg
10ml
- V8891 C$ 146.00 Add to cart

P450-Glo™ CYP2D6 Assay

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P450-Glo™ CYP2D6 Assay

 Components

  • Reconstitution Buffer with esterase

    V144B1 x 50ml
  • Luciferin Detection Reagent

    V859B1 x 1 each
  • Luciferin-ME EGE

    V869B1 x 900μg
50ml
- V8892 C$ 429.00 Add to cart


Available Separately

PRODUCT SIZE CONC CATALOG # *List Price ORDER QTY. Add to Cart

NADPH Regeneration System

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NADPH Regeneration System

 Components

  • Solution A—NADPH Regeneration System

    V952A1 x 2.75ml
  • Solution B—NADPH Regeneration System

    V953A1 x 600μl
1,000 assays
- V9510 C$ 139.00 Add to cart

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Storage Conditions

Store the CYP1A2, CYP2C9 and CYP3A4 membranes at –70°C. Cytochrome P450 may lose activity with repeated freeze-thaw cycles. Avoid multiple freeze-thaw cycles by dispensing the CYP1A2, CYP2C9 and CYP3A4 membranes into single-use aliquots (e.g., 50μl for 96 reactions). Store aliquots at –70°C. All other components can be stored at –20°C or –70°C and protected from light.

For product intended use please see Patents & Disclaimers tab.

Use Restrictions

V8421, V8422, V9001, V9002, V8911, V8912, V8901, V8902, V8751, V8752, V8761, V8762, V8771, V8772, V8781, V8782, V8791, V8792, V8801, V8802, V8811, V8812, V8881, V8882, V8891, V8892, V9510 For Research Use Only. Not for Use in Diagnostic Procedures.

Patents - Disclaimers

V8421, V8422, V9001, V9002, V8911, V8912, V8901, V8902, V8751, V8752, V8761, V8762, V8771, V8772, V8781, V8782, V8791, V8792, V8801, V8802, V8811, V8812, V8881, V8882, V8891, V8892 U.S. Pat. No. 7,692,022 and other patents pending.

V8421, V8422, V9001, V9002, V8911, V8912, V8901, V8902, V8751, V8752, V8761, V8762, V8771, V8772, V8781, V8782, V8791, V8792, V8801, V8802, V8811, V8812, V8881, V8882, V8891, V8892 Patent Pending.

V8421, V8422, V9001, V9002, V8911, V8912, V8901, V8902, V8751, V8752, V8761, V8762, V8771, V8772, V8781, V8782, V8791, V8792, V8801, V8802, V8811, V8812, V8881, V8882, V8891, V8892 U.S. Pat. Nos. 6,602,677, 7,241,584 and 8,030,017 and other patents and patents pending.

V8421, V8422, V9001, V9002, V8911, V8912, V8901, V8902, V8751, V8752, V8761, V8762, V8771, V8772, V8781, V8782, V8791, V8792, V8801, V8802, V8811, V8812, V8881, V8882, V8891, V8892 The method of recombinant expression of Coleoptera luciferase is covered by U.S. Pat. Nos. 5,583,024, 5,674,713 and 5,700,673.

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