The need to study coordinated signaling of kinase cascades in response to a variety of extracellular stimuli is critical to advances in fundamental cell biology and disease mechanisms. The availability of highly selective phosphorylation-specific antibodies that selectively target the active form of the ERK/MAP enzymes provides a powerful new approach to unraveling the regulation of these pathways.
Promega Notes 64, 17.
Melanie H. Cobb1 and Erik M. Schaefer2
1Department of Pharmacology, University of Texas Southwestern Medical Center; 2Promega Corporation