Literature # 9PIV631
Protein Phosphatase-2A (PPase-2A) is a serine/threonine phosphatase that was purified based on its ability to dephosphorylate the a-subunit of phosphorylase kinase. With its 36-38kDa catalytic subunit, PPase-2A has broad substrate specificity and may play a regulatory role in DNA replication, transcription, protein synthesis, mitosis and glycogen metabolism. PPase-2A is stimulated in vitro by basic proteins such as protamine, histones and polylysine. The enzyme is inhibited by several environmental toxins and tumor promoters such as okadaic acid and microcystin-LR. Promega's PPase-2A Catalytic Subunit is isolated from rabbit skeletal muscle.
Printed in USA. Revised 3/06.