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Signal Integration and Activation of MAP JNK and p38 Kinase Pathways in 293 Cells

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Abstract

The need to study coordinated signaling of kinase cascades in response to a variety of extracellular stimuli is critical to advances in fundamental cell biology and disease mechanisms. The availability of highly selective phosphorylation-specific antibodies that selectively target the active form of the ERK/MAP enzymes provides a powerful new approach to unraveling the regulation of these pathways.

Promega Notes 64, 17.

Melanie H. Cobb1 and Erik M. Schaefer2

1Department of Pharmacology, University of Texas Southwestern Medical Center; 2Promega Corporation

Publication Date: 1997

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