F13B, coagulation factor XIII B chain

F13B, coagulation factor XIII B chain

• This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]

• Gene Synonyms (FXIIIB, coagulation factor XIII B chain, TGase, coagulation factor XIII, B polypeptide, fibrin-stabilizing factor B subunit, protein-glutamine gamma-glutamyltransferase B chain, transglutaminase B chain,)
• NCBI Gene ID: 2165
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P05160
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

coagulation factor XIII B chain interacts with:

• fibrinogen gamma chain

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