- Gene Overview
- Interaction Network
- Sequence Verification
ACER1, alkaline ceramidase 1
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Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine (Houben et al., 2006 [PubMed 16477081]; Sun et al., 2008 [PubMed 17713573]).[supplied by OMIM, Jul 2010]
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Gene Synonyms (ALKCDase1, ASAH3, alkaline ceramidase 1, CTB-180A7.3, N-acylsphingosine amidohydrolase (alkaline ceramidase) 3, N-acylsphingosine amidohydrolase 3, acylsphingosine deacylase 3, alkCDase 1, alkaline CDase 1,)
- NCBI Gene ID:
125981
- Species:
Homo sapiens (Human)
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UNIPROT ID#>>Q8TDN7
- View the NCBI Database
for this Gene »
Gene products are often involved in multiple pathways and networks within a living
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alkaline ceramidase 1 interacts with:
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