EME1, essential meiotic structure-specific endonuclease 1

EME1, essential meiotic structure-specific endonuclease 1

• This gene encodes a protein that complexes with methyl methanesulfonate-sensitive UV-sensitive 81 protein to form an endonuclease complex. The encoded protein interacts with specifc DNA structures including nicked Holliday junctions, 3'-flap structures and aberrant replication fork structures. This protein may be involved in repairing DNA damage and in maintaining genomic stability. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

• Gene Synonyms (MMS4L, SLX2A, crossover junction endonuclease EME1, MMS4 homolog, SLX2 structure-specific endonuclease subunit homolog A, essential meiotic endonuclease 1 homolog 1, essential meiotic endonuclease 1 homolog 2, hMMS4, homolog of yeast EME1 endonuclease,)
• NCBI Gene ID: 146956
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q96AY2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

essential meiotic structure-specific endonuclease 1 interacts with:

• indoleamine 2,3-dioxygenase 2
  kinesin family member 18A
  RNA binding motif protein 33
  SLX1 homolog A, structure-specific endonuclease subunit

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.