ZUP1, zinc finger containing ubiquitin peptidase 1

ZUP1, zinc finger containing ubiquitin peptidase 1

• This gene encodes a protein containing zinc finger motifs and a cysteine peptidase domain. The encoded protein functions as a K63-specific de-ubiquitinating enzyme that specifically cleaves long K63-linked polyubiquitin chains in the middle of a chain (i.e. "endo cleavage) rather than by removing the terminal ubiquitin from a chain. This enzyme is thought to be involved in the regulation of DNA repair by cleaving K63-linked ubiquitin chains at repair foci. This protein is related to proteases for the ubiquitin-like modifiers Ufm1 (ubiquitin fold modifier 1) and Atg8/Gabarapl2, but does not have any activity on these modifiers. [provided by RefSeq, Mar 2018]

• Gene Synonyms (zinc finger-containing ubiquitin peptidase 1, lys-63-specific deubiquitinase ZUFSP, ubiquitin carboxyl-terminal hydrolase ZUFSP, zinc finger with UFM1-specific peptidase domain protein, C6orf113, DUB, ZUFSP,)
• NCBI Gene ID: 221302
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A0S2Z644
  UNIPROT ID#>>Q96AP4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

zinc finger containing ubiquitin peptidase 1 interacts with:

• assembly factor for spindle microtubules
  filaggrin family member 2
  FRY like transcription coactivator
  hornerin
  keratin 77
  keratinocyte proline rich protein
  kinesin family member 7
  RPTOR independent companion of MTOR complex 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.