MAGEB1, MAGE family member B1

MAGEB1, MAGE family member B1

• This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is localized in the DSS (dosage-sensitive sex reversal) critical region, and expressed in testis and in a significant fraction of tumors of various histological types. This gene and other MAGEB members are clustered on chromosome Xp22-p21. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene, however, the full length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]

• Gene Synonyms (CT3.1, DAM10, MAGE-Xp, MAGEL1, melanoma-associated antigen B1, DSS/AHC critical interval MAGE superfamily 10, MAGE-B1 antigen, MAGE-XP antigen, cancer/testis antigen 3.1, cancer/testis antigen family 3, member 1, melanoma antigen family B, 1, melanoma antigen family B1,)
• NCBI Gene ID: 4112
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P43366
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

MAGE family member B1 interacts with:

• EP300 interacting inhibitor of differentiation 2
  EP300 interacting inhibitor of differentiation 3
  MDM4 regulator of p53
  NEDD4 like E3 ubiquitin protein ligase
  NSE4 homolog A, SMC5-SMC6 complex component
  SRSF protein kinase 1
  SRSF protein kinase 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.