KREMEN2, kringle containing transmembrane protein 2

KREMEN2, kringle containing transmembrane protein 2

• This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

• Gene Synonyms (kremen protein 2, dickkopf receptor 2, kringle domain-containing transmembrane protein 2, kringle-containing protein marking the eye and the nose, KRM2,)
• NCBI Gene ID: 79412
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q53F67
  UNIPROT ID#>>Q8NCW0
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

kringle containing transmembrane protein 2 interacts with:

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.