GTF2A2, general transcription factor IIA subunit 2

GTF2A2, general transcription factor IIA subunit 2

• Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and the general initiation factors TFIIA, TFIIB (MIM 189963), TFIID (MIM 313650), TFIIE (MIM 189962), TFIIF (MIM 189968), TFIIG/TFIIJ, and TFIIH (MIM 189972). The first step involves recognition of the TATA element by the TATA-binding subunit (TBP; MIM 600075) and may be regulated by TFIIA, a factor that interacts with both TBP and a TBP-associated factor (TAF; MIM 600475) in TFIID. TFIIA has 2 subunits (43 and 12 kD) in yeast and 3 subunits in higher eukaryotes. In HeLa extracts, it consists of a 35-kD alpha subunit and a 19-kD beta subunit encoded by the N- and C-terminal regions of GTF2A1 (MIM 600520), respectively, and a 12-kD gamma subunit encoded by GTF2A2 (DeJong et al., 1995 [PubMed 7724559]).[supplied by OMIM, Mar 2008]

• Gene Synonyms (transcription initiation factor IIA subunit 2, TFIIA gamma subunit, TFIIA p12 subunit, general transcription factor IIA 2, general transcription factor IIA, 2, 12kDa, transcription initiation factor IIA gamma chain, HsT18745, T18745, TF2A2, TFIIA, TFIIA-12, TFIIA-gamma, TFIIAS,)
• NCBI Gene ID: 2958
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P52657
  UNIPROT ID#>>B2R506
  UNIPROT ID#>>A0A024R5Z5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

general transcription factor IIA subunit 2 interacts with:

• general transcription factor IIA subunit 1 like
  general transcription factor IIA subunit 2
  general transcription factor IIE subunit 1
  heat shock transcription factor 1
  protein tyrosine phosphatase non-receptor type 11
  RNA polymerase II subunit A
  TATA-box binding protein
  TATA-box binding protein associated factor 4
  TATA-box binding protein like 1
  telomeric repeat binding factor 1
  telomeric repeat binding factor 2
  tripartite motif containing 7

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