SAA1, serum amyloid A1

SAA1, serum amyloid A1

• This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11. [provided by RefSeq, Feb 2016]

• Gene Synonyms (serum amyloid A-1 protein, serum amyloid A protein, tumor protein p53 inducible protein 4, PIG4, SAA, SAA2, TP53I4,)
• NCBI Gene ID: 6288
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P0DJI8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

serum amyloid A1 interacts with:

• laminin subunit alpha 1
  selenoprotein S
  serum amyloid A1
  vitamin K epoxide reductase complex subunit 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.